Effects of medial septal stimulation & its blockade with atropine on hippocampal rhythmical slow activity in free-moving rabbits.
Artigo
em Inglês
| IMSEAR
| ID: sea-24177
ABSTRACT
The influence of the medial septal nucleus (MSN) on hippocampal rhythmical slow activity (RSA) was investigated in hunger motivated free-moving rabbits. Single unit activity of 29 CA3 dorsal hippocampal neurones was studied under two paradigms viz., electrical stimulation (3v/1msec/5Hz) and chemical blockade of atropine-sensitive medial septal cells (dose of 5 micrograms in 5 microliters). The analysis of interspike interval sample histograms recorded with Apple II, along with single unit neuronal spikes recorded on polygraph showed bimodal pattern with two peaks; one at bin 10-20 (high frequency) and second at bin 100-300 (theta frequency). On stimulation of MSN, there was total suppression of bin 100-300 with peaks at bin 1-20 and at bin greater than 1000 (very low frequency). Blockade of cholinergic receptors at MSN showed reduction of bin 100-300 and peak at bin 700- greater than 1000; this was followed by gradual decrease of spike's amplitude and thereafter its total abolition. The results indicate that the septal region is not a pacemaker per se in the genesis of hippocampal RSA (theta rhythm), but serves more in the nature of a relay station for a number of inputs and that its influence on the hippocampal electrical activity depends on the integrity of cholinergic inputs, be it from hippocampus proper or from mid-brain reticular formation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Periodicidade
/
Coelhos
/
Atropina
/
Núcleos Septais
/
Fome
/
Estimulação Elétrica
/
Hipocampo
/
Animais
/
Atividade Motora
/
Neurônios
Idioma:
Inglês
Ano de publicação:
1990
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS