Gastroprotective effect of Cissus quadrangularis extract in rats with experimentally induced ulcer.
Artigo
em Inglês
| IMSEAR
| ID: sea-24344
ABSTRACT
BACKGROUND & OBJECTIVES:
Most of the non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin cause gastric ulcer. In order to study the gastroprotective effect of Cissus quadrangularis extract (CQE), this study was undertaken on aspirin-induced ulcerogenesis in pyloric ligated (ASP-PL) model in rats.METHODS:
To assess the possible antiulcer effect of CQE, lesion index, gastric secretions glycoprotein levels, non-protein sulphydryls (NPSH) and adherent mucus content were determined in ASP-PL induced gastric mucosal injury in rats.RESULTS:
Pretreatment with CQE significantly prevented the gastric mucosal lesion development and decreased the gastric toxicity produced by ulcerogen. In addition, ulcerated rats showed depletion of gastric wall mucus, glycoproteins and NPSH levels whereas treatment with CQE reverted this decline in ASP-PL induced rats. Histological studies confirmed the results. INTERPRETATION &CONCLUSION:
The present finding suggests that CQE promotes ulcer protection by the decrease in ulcer index, gastric secretions and increase in the glycoprotein level, gastric mucin content and NPSH concentration. CQE may protect the gastric mucosa against ulceration by its antisecretory and cytoprotective property.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Oxirredutases
/
Ratos
/
Úlcera Gástrica
/
Contagem de Células Sanguíneas
/
Análise Química do Sangue
/
Masculino
/
Extratos Vegetais
/
Glicoproteínas
/
Análise de Variância
/
Cissus
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
2006
Tipo de documento:
Artigo
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