Association of angiotensin converting enzyme (ACE) gene polymorphism with hypertension in a Bangladeshi population.
Bangladesh Med Res Counc Bull
;
1998 Dec; 24(3): 55-9
Artigo
em Inglês
| IMSEAR
| ID: sea-244
ABSTRACT
The association of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with hypertension has not been confirmed. Inconsistencies may be due to the differences of background population characteristics. Till date, there has been no report in Bangladeshi population. This study was to examine the association of ACE (I/D) polymorphism with hypertension. Fifty-one primary hypertensives and fifty-two normotensives were recruited from a hospital in Dhaka city. Height, weight and blood pressure were measured. ACE (I/D) genotypes was established using polymerase chain reaction protocol. The genotype and allele frequencies did not differ significantly (P > 0.05) between the groups. In logistic regression analysis, adjusted for age, sex and body mass index, the genotypes were not associated with hypertension (DD vs II Adds ratio = 2.6, P = 0.34; ID vs II 0.4, 0.23; ID + DD vs II 0.8, 0.69). In this hospital-based sample of Bangladeshi people, significant association of ACE I/D genotype with hypertension was not observed.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Polimorfismo Genético
/
Bangladesh
/
Feminino
/
Humanos
/
Masculino
/
Estudos de Casos e Controles
/
Modelos Logísticos
/
Reação em Cadeia da Polimerase
/
Peptidil Dipeptidase A
/
Adulto
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Bangladesh Med Res Counc Bull
Ano de publicação:
1998
Tipo de documento:
Artigo
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