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Effect of subacute insecticide exposure on body weight, drug responses & electrical convulsions in mice.
Artigo em Inglês | IMSEAR | ID: sea-24459
ABSTRACT
Effect of subacute insecticide exposure was studied in male albino mice treated with phosphamidon, propoxur or aldrin at 1/40 LD50 dose intraperitoneally daily for 8 wk. The parameters studies included body weight, pentobarbitone (50 mg/kg) sleeping time, chlorpromazine (6 mg/kg) induced motor incoordination and convulsions induced by leptazol (100 mg/kg) and electrical stimulation (18 mA for 0.2 msec). While body weight and electrically induced convulsions were not affected, the effect of various drugs was significantly decreased. The observed changes may be due to the induction of hepatic drug metabolising enzymes by the insecticides. The study suggests that certain dose adjustment of drugs may be necessary in those exposed to insecticides over long periods.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Pentobarbital / Pentilenotetrazol / Convulsões / Peso Corporal / Masculino / Resíduos de Praguicidas / Clorpromazina / Interações Medicamentosas / Inseticidas / Animais Idioma: Inglês Ano de publicação: 1990 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Pentobarbital / Pentilenotetrazol / Convulsões / Peso Corporal / Masculino / Resíduos de Praguicidas / Clorpromazina / Interações Medicamentosas / Inseticidas / Animais Idioma: Inglês Ano de publicação: 1990 Tipo de documento: Artigo