Ultrastructural study on the antileishmanial effect of 1,2-dimethyl-3-methoxy carbonyl-4-(2-nitro-4,5-dimethoxyphenyl) pyrrole in hamsters.
Artigo
em Inglês
| IMSEAR
| ID: sea-24914
ABSTRACT
An ultrastructure study was carried out on the effect of a standard drug sodium stibogluconate and a newly identified active CDRI compound 87/305 [1,2-dimethyl-3-methoxy carbonyl-4-(2-nitro-4,5-dimethoxyphenyl) pyrrole] on amastigotes of Leishmania donovani in macrophage cells of spleen of infected hamsters. While Na-stibogluconate exerted its effect by activating the digestion capacity of host macrophages, compound 87/305 was directly lethal to the parasites without, exerting any effect on the host cells.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pirróis
/
Baço
/
Leishmania donovani
/
Masculino
/
Microscopia Eletrônica
/
Cricetinae
/
Gluconato de Antimônio e Sódio
/
Leishmaniose Visceral
/
Animais
/
Antiprotozoários
Idioma:
Inglês
Ano de publicação:
1991
Tipo de documento:
Artigo
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