Stimulation of the absorption of macromolecules in Giardia lamblia infected mice intestine.
Artigo
em Inglês
| IMSEAR
| ID: sea-25648
ABSTRACT
The absorption of 125I-labelled bovine serum albumin, gamma-globulin and alpha-lactalbumin was considerably enhanced in G. lamblia infected Swiss mice intestine compared to uninfected controls. The binding of 125I-proteins to brush border membrane was however, significantly (P less than 0.01) low in infected animals. Kinetic studies with gamma-globulin binding to brush borders revealed a decrease in the number of binding sites in infected animals (1.52) compared to controls (2.86 micrograms/mg protein) with no change in the affinity constant (47.60 micrograms/ml) under these conditions. These findings suggest that G. lamblia infection in mice leads to enhanced macromolecular absorption which seems unrelated to the binding of proteins to epithelial cell surface.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Masculino
/
Gama-Globulinas
/
Soroalbumina Bovina
/
Giardíase
/
Modelos Animais de Doenças
/
Absorção Intestinal
/
Lactalbumina
/
Animais
/
Camundongos
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
1990
Tipo de documento:
Artigo
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