Characterization of third beta-chain variant in Rattus rattus rufescens.
Indian J Biochem Biophys
;
1990 Jun; 27(3): 136-40
Artigo
em Inglês
| IMSEAR
| ID: sea-26303
ABSTRACT
Different molecular forms of hemoglobins of locally available murines, represented by Rattus rattus rufescens, have been investigated and the probable genetic mechanisms leading to the observed heterogenicity in the hemoglobin phenotypes are discussed. Each fraction was isolated in chromatographically pure form, identified and characterised structurally to establish their alpha- and non-alpha-chain constitution. Six molecular forms of component hemoglobins were identified from a wild population of R. rattus rufescens. The present study suggests five different globin chains in the hemoglobin of house rats (Rattus rattus rufescens). There are apparently two alpha-chains, namely alpha I and alpha II, and three different beta-chains, viz. beta I, beta II and beta III. The invariable presence, though at varying concentrations, of all these five globin chains implicates a gene duplication at the alpha-chain loci and a gene triplication at the beta-chain loci, the latter being a rather rare and unique genetic event.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Polimorfismo Genético
/
Ratos
/
Variação Genética
/
Mapeamento de Peptídeos
/
Hemoglobinas
/
Eletroforese em Gel de Amido
/
Animais
/
Muridae
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1990
Tipo de documento:
Artigo
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