Inhibition of two HMP shunt pathway enzymes by fatty acids and their CoA esters in developing human brain: role of fatty acid binding protein.
Indian J Biochem Biophys
;
1994 Dec; 31(6): 464-8
Artigo
em Inglês
| IMSEAR
| ID: sea-26350
ABSTRACT
Inhibitory effects of fatty acids and their CoA esters on glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities of human fetal brain cytosol have been studied. Purified human fetal brain fatty acid binding protein reverses the inhibitory effects of palmitoyl-CoA and oleic acid on glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities in human fetal brain cytosol. This protein, when added alone, activates the enzymes. Levels of fatty acid binding proteins as well as the activities of these two HMP shunt pathway enzymes, which provide cofactors like NADPH for reductive biosynthesis, increase with gestation. These results indicate that a relationship exists between the high demand for fatty acids and synthesis of cofactors for lipid biosynthesis in developing brain.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Via de Pentose Fosfato
/
Fosfogluconato Desidrogenase
/
Humanos
/
Acil Coenzima A
/
Proteínas de Transporte
/
Proteínas Supressoras de Tumor
/
Ésteres
/
Proteínas de Ligação a Ácido Graxo
/
Ácidos Graxos
/
Desenvolvimento Embrionário e Fetal
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1994
Tipo de documento:
Artigo
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