Mechanism of photosensitization of glioblastoma and neuroblastoma cells by merocyanine 540: a lipid peroxidation study.
Indian J Biochem Biophys
;
1997 Aug; 34(4): 379-84
Artigo
em Inglês
| IMSEAR
| ID: sea-26398
ABSTRACT
Mechanism of merocyanine 540 (MC540) mediated photosensitization in glioblastoma (U-87MG) and neuroblastoma (Neuro 2a) cells was investigated. Photoinduced lipid peroxidation was measured in the presence of mechanistic probes-deuterium oxide (D2O), sodium azide, superoxide dismutase (SOD), mannitol and sodium benzoate. In both the types of cells, the photoinduced lipid peroxidation was enhanced in D2O whereas it showed inhibition in the presence of sodium azide. SOD also inhibited the lipid peroxidation while sodium benzoate and mannitol had no effect. These results suggest that photosensitization of U-87MG and Neuro 2a cells by MC 540 involves both type I (free radical mediated) and type II (singlet oxygen mediated) mechanisms.
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Índice:
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Assunto principal:
Pirimidinonas
/
Humanos
/
Ensaios de Seleção de Medicamentos Antitumorais
/
Células Tumorais Cultivadas
/
Peroxidação de Lipídeos
/
Fármacos Fotossensibilizantes
/
Glioblastoma
/
Animais
/
Camundongos
/
Neuroblastoma
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1997
Tipo de documento:
Artigo
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