A new fragmentation rearrangement of the N-terminal protected amino acids using ESI-MS/MS.
Indian J Biochem Biophys
;
2006 Dec; 43(6): 372-6
Artigo
em Inglês
| IMSEAR
| ID: sea-26618
ABSTRACT
A novel fragmentation rearrangement reaction with a carboxyl oxygen negative charge migration was observed in the N-terminal protected amino acids including Fmoc-protected phosphoserine. phosphothroenine, and phosphotyrosine and their analogues using the electrospray ionization tandem mass spectrometry (ESI-MS/MS). The possible mechanism of a five-membered ring transition state was proposed and supported by the further experiments. It was found that the tendency of the rearrangement was determined by the blocking status of its C-terminal and the reaction was proved to be independent of the N-terminal and side-chain protecting groups of the amino acids.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fragmentos de Peptídeos
/
Fosfopeptídeos
/
Espectrometria de Massas por Ionização por Electrospray
/
Fluorenos
/
Aminoácidos
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2006
Tipo de documento:
Artigo
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