Plausible involvement of extralysosomal proteinase in derangement of leucocytic Ca2+/Mg2+ ATPase in diabetes.
Indian J Biochem Biophys
;
1994 Jun; 31(3): 195-7
Artigo
em Inglês
| IMSEAR
| ID: sea-26660
ABSTRACT
Translocation of calcium activated neutral proteinase from cytosol to plasma membrane, concurrently with decrease in the activity of membrane bound Ca2+/Mg2+ ATPase has been detected in diabetic polymorphonuclear leucocytes. Plausible involvement of the extralysosomal proteinase in the derangement of the Ca2+/Mg2+ ATPase is indicated by non restoration of the enzyme activity on treatment with activators such as trypsin or calmodulin and enhanced membrane translocation of the proteinase observed with concomitant decrease in the activity of Ca2+/Mg2+ ATPase in normal neutrophils on insult with diabetic serum factor.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Calpaína
/
ATPase de Ca(2/) e Mg(2/)
/
Adulto
/
Diabetes Mellitus Tipo 2
/
Pessoa de Meia-Idade
/
Neutrófilos
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1994
Tipo de documento:
Artigo
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