Is the role of fatty acids only to provide membrane-anchor in fatty acylated proteins?
Artigo
em Inglês
| IMSEAR
| ID: sea-26829
ABSTRACT
A large number of proteins on the eukaryotic cell surface that play an important role in cellular metabolism are covalently modified with fatty acids like palmitic and myristic acids. While some of these proteins have transmembrane spanning segments, many others do not. Early hypothesis was that this co or posttranslational modification helped in membrane-association and the fatty acyl chain provided a stable membrane anchor. We have investigated the structure of peptides with these modifications and also their interaction with membranes. Our results indicate that the fatty acylated peptides, especially when the peptide segment is not hydrophobic, do not have strong affinity for membranes. The recent observations about the dynamic nature of fatty acid acylation as well as the importance of protein-protein interactions for function in fatty-acylated proteins suggest that membrane-association may involve factors other than only the fatty acid, either myristic or palmitic. Revised models depicting the possible role of fatty acids in modulating protein-protein interaction and their dynamics is presented.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Peptídeos
/
Conformação Proteica
/
Acilação
/
Membrana Celular
/
Ácido Palmítico
/
Ácido Mirístico
/
Ácidos Graxos
/
Lipoproteínas
/
Proteínas de Membrana
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
1997
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS