1H NMR investigation of the interaction of berberine and sanguinarine with DNA.
Indian J Biochem Biophys
;
1995 Apr; 32(2): 74-7
Artigo
em Inglês
| IMSEAR
| ID: sea-26870
ABSTRACT
Interaction of the alkaloids, berberine and sanguinarine with calf thymus DNA has been studied by 1H NMR. All proton resonances of the two compounds have been assigned using 2D-COSY, NOESY and ROESY spectra. Berberine has been found to partially intercalate into DNA, while sanguinarine shows normal intercalation and also binds more firmly to DNA. The NMR experiments indicate that sanguinarine is more potent than berberine in its activity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Prótons
/
Berberina
/
DNA
/
Bovinos
/
Espectroscopia de Ressonância Magnética
/
Alcaloides
/
Benzofenantridinas
/
Substâncias Intercalantes
/
Isoquinolinas
/
Animais
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1995
Tipo de documento:
Artigo
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