Polyene antibiotics in the membrane environment.
Indian J Biochem Biophys
;
1991 Aug; 28(4): 227-32
Artigo
em Inglês
| IMSEAR
| ID: sea-26901
ABSTRACT
The cytotoxic activity of the polyene antibiotics mainly depends on the appearance of the drug species which arises from drug-sterol complexation. The unsaturation and intact macrolide ring of the polyenes are the requirements for the biological activity. All the polyene antibiotics can form the complex with the sterol having 3 beta-OH group, and planar ring and a hydrophobic side chain. Aromatic polyene antibiotics with positively charged head group have been considered as most potential antifungal agents.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Esteróis
/
Relação Estrutura-Atividade
/
Portadores de Fármacos
/
Anfotericina B
/
Filipina
/
Lipossomos
/
Animais
/
Lipídeos de Membrana
/
Antibacterianos
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1991
Tipo de documento:
Artigo
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