Effect of administration of galactosamine hydrochloride on rat liver mitochondria.
Indian J Biochem Biophys
;
1997 Jun; 34(3): 296-301
Artigo
em Inglês
| IMSEAR
| ID: sea-27103
ABSTRACT
The effect of galactosamine on liver mitochondrial functions was studied in vivo in rats at 12hr, 24hr and 36hr after the administration of the drug. State 3 respiration decreased significantly with both NAD+ linked and FAD linked substrates. Respiratory control ratio, an index of membrane integrity and P/O ratio which is a measure of phosphorylation efficiency decreased significantly. There was a significant decrease in the activities of NADH dehydrogenase, succinate dehydrogenase and cytochrome oxidase. A significant decrease was also seen on membrane potential, cytochrome aa3, cytochrome b, cytochrome c and on phospholipids of mitochondria. The observed mitochondrial dysfunctions were related to increased lipid peroxidation, which could cause loss of membrane integrity and a decreased rate of phosphorylation. It is proposed that increased lipid peroxidation was responsible for the inhibition on both oxidation and phosphorylation in mitochondria in galactosamine treated rats.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosforilação
/
Ratos
/
Succinato Desidrogenase
/
Mitocôndrias Hepáticas
/
Complexo IV da Cadeia de Transporte de Elétrons
/
Respiração Celular
/
Citocromos
/
Transporte de Elétrons
/
Galactosamina
/
Peróxidos Lipídicos
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1997
Tipo de documento:
Artigo
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