Polyunsaturated fatty acids (PUFA) regulate neurotransmitter contents in rat brain.
Indian J Biochem Biophys
;
2001 Oct; 38(5): 327-30
Artigo
em Inglês
| IMSEAR
| ID: sea-27204
ABSTRACT
The effects of feeding of 6-propylthiouracil (6-PTU) and polyunsaturated fatty acids (PUFA) independently and in combination and administration (ip) of a single dose of triiodothyronine (T3) (2.5 microg/100 g body wt) along with feeding of 6-PTU and PUFA were studied in rat brain. Dopamine (DA), 5-hydroxytryptophan (5-HTP), serotonin (5-HT), 5-hydroxy indole acetic acid (5-HIAA), norepinephrine (NE) and epinephrine (EPI) contents were assayed in the hypothalamus and cerebral cortex regions. It was found that 6-PTU feeding resulted in decrease in dopamine, 5-HT, 5-HTP and 5-HIAA in both regions. In animals fed with PUFA followed by administration of T3, the DA level was found normal.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Propiltiouracila
/
Ratos
/
Encéfalo
/
Masculino
/
Monoaminas Biogênicas
/
Ratos Wistar
/
Dieta
/
Combinação de Medicamentos
/
Ácidos Graxos Insaturados
/
Hormônios
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2001
Tipo de documento:
Artigo
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