Localization of heme biosynthesis pathway enzymes in Plasmodium falciparum.
Indian J Biochem Biophys
;
2008 Dec; 45(6): 365-73
Artigo
em Inglês
| IMSEAR
| ID: sea-27212
ABSTRACT
Protein trafficking in the malarial parasite Plasmodium falciparum is dictated by a complex life-cycle that involves a variety of intra-cellular and host cell destinations, such as the mitochondrion, apicoplast, rhoptries and micronemes. Of these, the apicoplast and mitochondrion are believed to account for more than 10% of this traffic. Studies have shown that mechanisms for mitochondrion and apicoplast targeting are distinct, despite their close physical proximity. The heme biosynthesis pathway spans both these organelles, making trafficking studies crucial for the spatial demarcation of the constituent interactions. This minireview highlights the challenges in identifying the possible sub-cellular destinations of the heme pathway enzymes using gleanings from literature survey as well as focussed bioinformatic analysis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Plasmodium falciparum
/
Dados de Sequência Molecular
/
Proteínas de Protozoários
/
Sequência de Aminoácidos
/
Transporte Proteico
/
Heme
/
Animais
/
Mitocôndrias
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2008
Tipo de documento:
Artigo
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