Quantitative structure-activity relationship studies on benzodiazepine receptor binding: investigation of interaction model.
Indian J Biochem Biophys
;
1993 Jun; 30(3): 181-6
Artigo
em Inglês
| IMSEAR
| ID: sea-27332
ABSTRACT
With a view to providing perfection to the benzodiazepine receptor model proposed earlier [S P Gupta, R N Saha & V Mulchandani (1992) J. Mol. Recog, 5, 75-80] a few more QSAR studies on a series of 9-benzylpurines and tetracyclic 1,4-benzodiazepine derivatives have been made. The models showing the interaction of these compounds with the receptor are proposed. It is found that the receptor model, unlike the one proposed earlier, requires the presence of a polar site along with all the other essential sites.
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Assunto principal:
Conformação Proteica
/
Relação Estrutura-Atividade
/
Benzodiazepinas
/
Ligação Competitiva
/
Sítios de Ligação
/
Cinética
/
Estrutura Molecular
/
Receptores de GABA-A
/
Diazepam
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1993
Tipo de documento:
Artigo
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