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Developmentally-regulated cell surface N-linked oligosaccharides participate in intercellular cohesion in Dictyostelium discoideum.
Indian J Biochem Biophys ; 1993 Dec; 30(6): 376-81
Artigo em Inglês | IMSEAR | ID: sea-27343
ABSTRACT
The ability of purified plasma membrane glycoconjugates to inhibit the EDTA-resistant agglutination between aggregation-stage cells of Dictyostelium discoideum has suggested that receptor binding of these glycoconjugates provides a basis for cell-cell cohesion during aggregation. This has been tested by analysis of a series of mutants with different defects in the assembly of N-linked oligosaccharides. Mutant HL241 lacks outer branch components of N-linked oligosaccharides and fails to aggregate or express EDTA-resistant cohesion. HL244 makes unsulphated but otherwise normal N-linked oligosaccharides, generates multiple tips on aggregated cell mounds in some clones, and shows abnormally strong EDTA-resistant cohesion. Two mutants that are temperature-sensitive for complete processing of N-linked oligosaccharides are also temperature-sensitive for expression of both aggregation ability and EDTA-resistant cohesion. A revertant that recovered essentially normal N-linked oligosaccharide processing at the restrictive temperature has also recovered its ability to aggregate and to agglutinate in EDTA.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Oligossacarídeos / Glicoproteínas de Membrana / Dados de Sequência Molecular / Glicolipídeos / Membrana Celular / Sequência de Carboidratos / Aglutinação / Dictyostelium / Animais / Lipídeos de Membrana Idioma: Inglês Revista: Indian J Biochem Biophys Ano de publicação: 1993 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Oligossacarídeos / Glicoproteínas de Membrana / Dados de Sequência Molecular / Glicolipídeos / Membrana Celular / Sequência de Carboidratos / Aglutinação / Dictyostelium / Animais / Lipídeos de Membrana Idioma: Inglês Revista: Indian J Biochem Biophys Ano de publicação: 1993 Tipo de documento: Artigo