Kinetics and mechanisms of cholesterol esterase inhibition by cardiovascular drugs in vitro.
Indian J Biochem Biophys
;
2006 Feb; 43(1): 52-5
Artigo
em Inglês
| IMSEAR
| ID: sea-27416
ABSTRACT
Cardiovascular drugs such as lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride inhibit cholesterol esterase (CEase) in vitro. In the present paper, an attempt was made to determine kinetically the reaction mechanism for CEase inhibition by these drugs. The inhibition constant, Ki, for the mixed-type inhibition of CEase by these drugs in the presence of triton-X-100 or taurochloate were measured. Moreover, the pKi values were correlated with the molecular weights of these drugs. In conclusion, the fact that these drugs lower cholesterol levels in the plasma low-density lipoprotein may be partially due to the CEase inhibition by these drugs.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ácido Taurocólico
/
Cinética
/
Nifedipino
/
Fármacos Cardiovasculares
/
Esterol Esterase
/
Anlodipino
/
Octoxinol
/
Sinvastatina
/
Inibidores Enzimáticos
/
Hidralazina
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2006
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS