Carbohydrate induced modulation of cell membrane. IV: Interaction with mucin and fucoidan totally immobilizes the human platelet membrane.
Indian J Biochem Biophys
;
1996 Aug; 33(4): 308-10
Artigo
em Inglês
| IMSEAR
| ID: sea-27467
ABSTRACT
P selectins and E selectins are cell adhesion molecules that mediate the interaction of platelets and endothelial cells with neutrophils and monocytes. The proposed ligands for these receptors contain the Le(x) core, sialic acid and sulfated fucose. In this paper we report that binding of sialic acid markedly restricts the mobility of membrane proteins and lipids as studied by EPR spectroscopy using spin probes. Binding of mucin and fucoidan totally restricts the mobility probably due to cross-linking of the surface lectins. Binding of these ligands also resulted in an increase in the cytoplasmic viscosity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Polissacarídeos
/
Plaquetas
/
Humanos
/
Membrana Celular
/
Espectroscopia de Ressonância de Spin Eletrônica
/
Selectinas
/
Ligantes
/
Lipídeos de Membrana
/
Proteínas de Membrana
/
Mucinas
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1996
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS