Effect of perchlorate on mitochondrial function.
Indian J Biochem Biophys
;
1990 Feb; 27(1): 48-51
Artigo
em Inglês
| IMSEAR
| ID: sea-27583
ABSTRACT
Administration of sodium perchlorate to rats for 45 days leads to decreased activities of citric acid cycle enzymes. The oxidation of succinate both in state 3 and state 4 conditions and endogenous ATP content of mitochondria decreased during perchlorate toxicity. The significant decrease in cytochrome aa3 in perchlorate-treated rats may be one of the prime factors involved in the decreased rate of respiration. The permeability of mitochondria of perchlorate-treated rats is altered as indicated by increased oxidation of NADH and low respiratory control ratio (RCR).
Texto completo:
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Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Ratos Endogâmicos
/
Masculino
/
Mitocôndrias Hepáticas
/
Percloratos
/
Rim
/
Animais
/
Mitocôndrias
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1990
Tipo de documento:
Artigo
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