Wobble base-pairing in codon-anticodon interactions: a theoretical modelling study.
Indian J Biochem Biophys
;
2001 Feb-Apr; 38(1-2): 115-9
Artigo
em Inglês
| IMSEAR
| ID: sea-27945
ABSTRACT
The Crick wobble hypothesis attributes the phenomenon of codon degeneracy to a certain impreciseness of pairing between the third base of the codon and the first base of the anticodon. This theoretical study investigates the pairing properties of some wobble bases, including both, observed and unobserved pairs. Some wobble base-pairs are predicted to follow the Watson-Crick pairs in configuration and pairing facility, while others deviate from this norm. The observed UV pair is unique in that a pairing configuration may be suggested for it wherein the hydrogen-bonding involves the exocyclic 5-carboxymethoxy group of V. By comparing the theoretical data on the configurations of these pairs with the evidence for their existence/non-existence in nature, some guidelines emerge for differentiating between observed and unobserved base pairs on the basis of the pairing configuration.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Uracila
/
Simulação por Computador
/
Anticódon
/
Códon
/
DNA
/
Adenina
/
Pareamento de Bases
/
Citosina
/
Guanina
/
Ligação de Hidrogênio
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2001
Tipo de documento:
Artigo
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