Quantitative structure activity relationship (QSAR) studies of some substituted benzenesulphonyl glutamines as tumour suppressors.
Indian J Biochem Biophys
;
2001 Feb-Apr; 38(1-2): 120-3
Artigo
em Inglês
| IMSEAR
| ID: sea-27987
ABSTRACT
As a part of a composite programme of rational drug design (RDD), we had synthesized some substituted benzenesulphonyl glutamines and evaluated their inhibitory activities against Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. Quantitative structure activity relationship (QSAR) studies of these inhibitory activities using Fujita-Ban model as well as Modified Hansch-Fujita model gave excellent correlations (correlation coefficient r = 0.89 and 0.82 respectively). These results could be useful in designing 'lead' compound with potent inhibitory activity on DNA and RNA synthesis and tumour development.
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Índice:
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Assunto principal:
Relação Estrutura-Atividade
/
Benzenossulfonatos
/
DNA
/
RNA
/
Células Tumorais Cultivadas
/
Glutamina
/
Animais
/
Camundongos
/
Modelos Químicos
/
Modelos Teóricos
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2001
Tipo de documento:
Artigo
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