Influence of 7beta-hydroxycholesterol on glutathione status and nitric oxide production in macrophages: in vitro studies.
Indian J Biochem Biophys
;
2001 Jun; 38(3): 176-9
Artigo
em Inglês
| IMSEAR
| ID: sea-28189
ABSTRACT
Incubation of murine peritoneal macrophages with 7beta-hydroxycholesterol (7beta-OH) for 24 hr led to dose-dependent reduction in cellular glutathione content as well as nitrite levels in the medium. Treatment with an inorganic form of selenium, sodium selenite which is a potent antioxidant, elevated the cellular glutathione levels and decreased nitrite levels. Our results suggest that 7beta-OH may exert its pro-atherogenic effect by inhibiting glutathione synthesis and nitric oxide production by macrophages present in the arterial wall and thus, impair the cellular antioxidant defense system.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Artérias
/
Selênio
/
Fatores de Tempo
/
Células Cultivadas
/
Macrófagos Peritoneais
/
Relação Dose-Resposta a Droga
/
Glutationa
/
Glutationa Peroxidase
/
Hidroxicolesteróis
/
Animais
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2001
Tipo de documento:
Artigo
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