IRF-1 and IRF-2 as regulators of the interferon system and cell growth.
Indian J Biochem Biophys
;
1995 Oct; 32(5): 235-9
Artigo
em Inglês
| IMSEAR
| ID: sea-28347
ABSTRACT
Interferons (IFNs) are families of cytokines which have been discovered and extensively characterized in the context of host defense against viral infections. We have discovered two structurally related transcription factors, Interferon regulatory factor-1 (IRF-1) and IRF-2. These two factors, however, function not only as regulators of the IFN system, but are also key transcription factors in the regulation of cell cycle and apoptosis. These studies uncover a complex gene transcription network, by which the fate of cellular responses are determined depending on how the IRF transcription factors function in conjunction with other factors, and on the promoters of distinct genes under different conditions of the cells.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosfoproteínas
/
Proteínas Repressoras
/
Fatores de Transcrição
/
Humanos
/
Divisão Celular
/
Interferons
/
Proteínas de Ligação a DNA
/
Fator Regulador 1 de Interferon
/
Fator Regulador 2 de Interferon
/
Animais
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1995
Tipo de documento:
Artigo
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