A conserved epitope on nuclear pore phosphoproteins reflects cell division status.
Indian J Biochem Biophys
;
1994 Aug; 31(4): 243-8
Artigo
em Inglês
| IMSEAR
| ID: sea-28429
ABSTRACT
The nuclear pore complexes mediate the selective nuclear import of proteins in a signal- and energy-dependent process. We have earlier reported the characterization of a monoclonal antibody, Mab E2, that recognizes a novel class of nuclear pore phosphoproteins involved in signal-binding and protein transport. In the present study, we have analyzed the pattern of immunoreactivity of Mab E2 in cultured rat fibroblasts and have observed significant differences in the expression of epitopes in proliferating and quiescent cells. Furthermore, the common epitope recognized by Mab E2 is conserved across species, consistent with its essential role in nuclear protein import.
Texto completo:
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Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosfoproteínas
/
Ratos
/
Humanos
/
Dados de Sequência Molecular
/
Divisão Celular
/
Linhagem Celular
/
Sequência de Aminoácidos
/
Ratos Wistar
/
Animais
/
Proteínas de Membrana
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1994
Tipo de documento:
Artigo
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