Conformational transitions and specific heat anomaly in poly(dG-dC) and its methylated analogue.
Indian J Biochem Biophys
;
1992 Dec; 29(6): 449-57
Artigo
em Inglês
| IMSEAR
| ID: sea-28658
ABSTRACT
The Zimm and Bragg theory of the helix<-->coil transition has been modified to explain order<-->order transitions in polynucleotides, in particular B<-->Z<-->psi(-)<-->coil transitions in poly(dG-dC) and poly(dG-me5dC). Lambda anomalies in specific heat measurements around the transition point have also been explained by a further modification of the same theory. Theoretical results are found to be in good agreement with the experimental data. The nucleation parameter is consistent with the stabilization/destabilization of the ordered states (Z helix) under various environmental conditions, e.g. methylation of cytosine residue at C5 position or change in the cationic concentration of the solvent.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Polidesoxirribonucleotídeos
/
Termodinâmica
/
Calorimetria
/
Cinética
/
Temperatura Alta
/
Matemática
/
Conformação de Ácido Nucleico
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1992
Tipo de documento:
Artigo
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