Metabolism of 5-aminoquinoline with liver cytosol enzyme.
Indian J Biochem Biophys
;
1993 Aug; 30(4): 229-33
Artigo
em Inglês
| IMSEAR
| ID: sea-28724
ABSTRACT
In vitro oxidation and acetylation of 5-aminoquinoline by rabbit liver enzyme preparation has been investigated. Incubation of 5-aminoquinoline with cytosol fraction of the enzyme preparation in the presence of acetyl coenzyme-A gave rise to three different products, viz. 5-amino-2-hydroxy quinoline, 5-acetyl-aminoquinoline and 5-acetylamino-2-hydroxy quinoline due to the combined action of aldehyde oxidase and N-acetyl transferase. The metabolites thus obtained by enzyme catalysed reactions were isolated and separated by TLC, HPLC and subsequently characterised by IR and mass spectral fragmentation techniques.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Oxirredução
/
Acetilação
/
Coelhos
/
Acetiltransferases
/
Espectrometria de Massas
/
Feminino
/
Cinética
/
Biotransformação
/
Cromatografia Líquida de Alta Pressão
/
Cromatografia em Camada Fina
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1993
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS