In vitro stimulation of microsomal diethyl nitrosamine deethylase activity by vitamin K3 (menadione).
Indian J Biochem Biophys
;
1992 Apr; 29(2): 201-3
Artigo
em Inglês
| IMSEAR
| ID: sea-28871
ABSTRACT
Vitamin K3 (menadione) has been found to stimulate diethyl nitrosamine (DEN)-deethylase activity in rat liver microsomes. The vitamin also takes care of the inhibitory effect of the anaerobic conditions as well as those of cytochrome poisons like sodium azide and sodium cyanide, possibly through production of active oxygen species. The enzyme was also stimulated by H2O2 and SOD and inhibited by catalase, thereby suggesting that H2O2 or some derivatives of it may be the active oxygen species involved in the reaction.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Oxirredutases
/
Ratos
/
Superóxido Dismutase
/
Vitamina K
/
Masculino
/
Microssomos Hepáticos
/
Cinética
/
Ratos Wistar
/
Animais
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
1992
Tipo de documento:
Artigo
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