Your browser doesn't support javascript.
loading
Impact of chromium on lipoperoxidative processes and subsequent operation of the glutathione cycle in rat renal system.
Indian J Biochem Biophys ; 1992 Jun; 29(3): 287-90
Artigo em Inglês | IMSEAR | ID: sea-28971
ABSTRACT
Oral administration of K2Cr2O7 to male albino rats at an acute dose of 1500 mg/kg body wt/day for 3 days brought about sharp decrease in the activities of glucose-6-phosphate dehydrogenase and glutathione reductase of kidney epithelial cells. The scavenging system of kidney epithelium is also affected as evident by the highly significant fall in the activities of glutathione peroxidase, superoxide dismutase and catalase which ultimately leads to the increase in lipid peroxidation value in kidney cortical homogenate. However, glutathione-s-transferase activity in cytosol and glutathione and total thiol content in cortical homogenate were not altered. Chronic oral administration of K2Cr2O7 (300 mg/kg body wt/day) for 30 days to rats lead to elevation in the activities of glutathione peroxidase, glutathione reductase, glutathione-s-transferase, superoxide dismutase and catalase with no change in glucose-6-phosphate dehydrogenase activity in epithelial cells. This might lead to the increase in glutathione and total thiol status and decrease in lipid peroxidation value in whole homogenate system.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Peroxidases / Dicromato de Potássio / Ratos / Masculino / Peroxidação de Lipídeos / Glucosefosfato Desidrogenase / Glutationa / Córtex Renal / Animais Idioma: Inglês Revista: Indian J Biochem Biophys Ano de publicação: 1992 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Peroxidases / Dicromato de Potássio / Ratos / Masculino / Peroxidação de Lipídeos / Glucosefosfato Desidrogenase / Glutationa / Córtex Renal / Animais Idioma: Inglês Revista: Indian J Biochem Biophys Ano de publicação: 1992 Tipo de documento: Artigo