Induction of rifampicin metabolism during treatment of tuberculous patients with daily and fully intermittent regimens containing the drug.
Indian J Chest Dis Allied Sci
;
1989 Oct-Dec; 31(4): 251-7
Artigo
em Inglês
| IMSEAR
| ID: sea-29882
ABSTRACT
Self-induction of rifampicin metabolism during daily and intermittent chemotherapy was studied by monitoring the changes in the serum half-life of the drug over a 4-week period in patients with pulmonary tuberculosis. Rifampicin 450 mg was administered to 8 patients who received treatment daily, 7 on thrice-weekly and 7 others on twice-weekly treatment. Serum half-life was computed from concentrations of the drug determined at 3, 4 1/2 and 6 hours after drug administration, on admission and at 1, 2 and 4 weeks after start of treatment. In the daily series, the mean serum half-life decreased from 4.9 hours on admission to 3.6 hours at 1 week (P = 0.02), and treatment beyond this had no further effect. In the thrice-weekly series, maximal induction was observed at the 2nd week, the mean values on admission and at 2 weeks being 5.8 and 3.7 hours, respectively (P less than 0.01). In the twice-weekly series, maximal induction was observed only at the 4th week, the mean values on admission and at 4 weeks being 4.9 and 3.7 hours, respectively (P less than 0.01). Serum activity of gamma glutamyl transferase was not found to be a suitable in vivo marker to monitor induction of the hepatic microsomal enzymes as no significant changes were observed in the activity of this enzyme in any of the 3 series during the 4-week period.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pirazinamida
/
Rifampina
/
Tuberculose Pulmonar
/
Humanos
/
Esquema de Medicação
/
Microssomos Hepáticos
/
Indução Enzimática
/
Quimioterapia Combinada
/
Etambutol
/
Gama-Glutamiltransferase
Idioma:
Inglês
Revista:
Indian J Chest Dis Allied Sci
Ano de publicação:
1989
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS