Study of thiobarbituric reactive substances and total reduced glutathione as indices of oxidative stress in chronic smokers with and without chronic obstructive pulmonary disease.
Indian J Chest Dis Allied Sci
;
2007 Jan-Mar; 49(1): 9-12
Artigo
em Inglês
| IMSEAR
| ID: sea-30259
ABSTRACT
BACKGROUND:
The imbalance between oxidants and antioxidants is thought to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD).METHODS:
Biomarkers of lipid oxidation such as thiobarbituric reactive substances (TBARs), total reduced glutathione (GSH) were estimated in chronic smokers with and without COPD, and non-smokers.RESULTS:
The following subjects (all males) were studied (i) chronic smokers (32.5 +/- 8.6 pack years) with stable COPD (n = 20; mean age 47.2 +/- 7.8 years); (ii) chronic smokers (6.3 +/- 1.9 pack years) without COPD (n = 20; mean age 35.3 +/- 4.5 years); and (iii) non-smokers (n = 20; mean age 37.5 +/- 5.5 years). The mean TBARs levels (nmol of malondialdehyde per ml of plasma) were higher among smokers with COPD (5.72 +/- 1.02) when compared with smokers without COPD (4.85 +/- 0.97) and non-smokers (2.58 +/- 0.56) (p < 0.001). The mean GSH levels (micromol/mg of protein) were significantly higher in non-smokers (0.163 +/- 0.113) compared to smokers with COPD (0.083 +/- 0.05) and those without COPD (0.050 +/- 0.051) (p < 0.001). There was no statistically significant difference in the plasma GSH levels among smokers with and without COPD (p > 0.05).CONCLUSIONS:
Our observations demonstrate increased lipid peroxidation because of oxidative stress due to smoking.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Masculino
/
Fumar
/
Estudos de Casos e Controles
/
Substâncias Reativas com Ácido Tiobarbitúrico
/
Estresse Oxidativo
/
Adulto
/
Doença Pulmonar Obstrutiva Crônica
/
Glutationa
/
Pessoa de Meia-Idade
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Chest Dis Allied Sci
Ano de publicação:
2007
Tipo de documento:
Artigo
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