Genetic variants of beta-globin gene in Thai malaria patients.
Southeast Asian J Trop Med Public Health
;
2003 ; 34 Suppl 2(): 29-31
Artigo
em Inglês
| IMSEAR
| ID: sea-30636
ABSTRACT
Hemoglobin E (E26K variant of beta-globin gene) causing hemoglobinopathy is commonly observed in parts of Thailand, regardless of the hematologic disadvantage of the homozygotes. In order to detect further variants of the beta-globin gene, we performed variation screening for exon 1 of the beta-globin gene in 64 adult patients with P. falciparum malaria, living in northwest Thailand. We identified E26K and two novel variants, 59C>T and IVS+1G>T. IVS+1G>T lies on the splice donor site, and a substitution of A for G at the same site (IVS+1G>A) is known to be linked to beta-thalassemia. Thus, the biological significance of IVS+1G>T and its association with malarial infection should be clarified in future studies.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tailândia
/
Variação Genética
/
Humanos
/
Beta-Globulinas
/
Hemoglobina E
/
Reação em Cadeia da Polimerase
/
Malária Falciparum
/
Animais
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
2003
Tipo de documento:
Artigo
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