Initial treatment of cryptococcal meningitis in AIDS.
Southeast Asian J Trop Med Public Health
;
2005 Jan; 36(1): 170-3
Artigo
em Inglês
| IMSEAR
| ID: sea-30987
ABSTRACT
The comparison of initial treatment with amphotericin B (0.7 mg/kg/d) plus rifampin (600 mg/d) with amphotericin B (0.7 mg/kg/d) alone for 2 weeks, both followed by fluconazole (400 mg/ d) for 8 weeks in the acute treatment of cryptococcal meningitis in AIDS by an open- randomized, controlled, prospective clinical trial is reported. Twenty patients were enrolled in each group. There were no significant differences between the groups in regard to a negative CSF culture for Cryptococcus neoformans in the 2nd and 10th weeks of treatment, time until normal body temperature after treatment, number of patients who died, and persistence of high CSF pressure after completion of treatment. Elevated intracranial pressure was an important factor associated with the patients who died. These results indicate that the combination of amphotericin B plus rifampin is not superior to amphotericin B alone.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Rifampina
/
Feminino
/
Humanos
/
Masculino
/
Fluconazol
/
Anfotericina B
/
Estudos Prospectivos
/
Meningite Criptocócica
/
Infecções Oportunistas Relacionadas com a AIDS
/
Adulto
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
2005
Tipo de documento:
Artigo
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