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Initial treatment of cryptococcal meningitis in AIDS.
Southeast Asian J Trop Med Public Health ; 2005 Jan; 36(1): 170-3
Artigo em Inglês | IMSEAR | ID: sea-30987
ABSTRACT
The comparison of initial treatment with amphotericin B (0.7 mg/kg/d) plus rifampin (600 mg/d) with amphotericin B (0.7 mg/kg/d) alone for 2 weeks, both followed by fluconazole (400 mg/ d) for 8 weeks in the acute treatment of cryptococcal meningitis in AIDS by an open- randomized, controlled, prospective clinical trial is reported. Twenty patients were enrolled in each group. There were no significant differences between the groups in regard to a negative CSF culture for Cryptococcus neoformans in the 2nd and 10th weeks of treatment, time until normal body temperature after treatment, number of patients who died, and persistence of high CSF pressure after completion of treatment. Elevated intracranial pressure was an important factor associated with the patients who died. These results indicate that the combination of amphotericin B plus rifampin is not superior to amphotericin B alone.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Rifampina / Feminino / Humanos / Masculino / Fluconazol / Anfotericina B / Estudos Prospectivos / Meningite Criptocócica / Infecções Oportunistas Relacionadas com a AIDS / Adulto Tipo de estudo: Ensaio Clínico Controlado / Estudo observacional Idioma: Inglês Revista: Southeast Asian J Trop Med Public Health Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Rifampina / Feminino / Humanos / Masculino / Fluconazol / Anfotericina B / Estudos Prospectivos / Meningite Criptocócica / Infecções Oportunistas Relacionadas com a AIDS / Adulto Tipo de estudo: Ensaio Clínico Controlado / Estudo observacional Idioma: Inglês Revista: Southeast Asian J Trop Med Public Health Ano de publicação: 2005 Tipo de documento: Artigo