Molecular evolution, distribution and genetic relationship among the dengue 2 viruses isolated from different clinical severity.
Southeast Asian J Trop Med Public Health
;
2000 Jun; 31(2): 266-72
Artigo
em Inglês
| IMSEAR
| ID: sea-31121
ABSTRACT
Twenty-two strains of dengue 2 virus, isolated in China, Latin America, New Guinea and Thailand were subjected to phylogenetic analysis. The UPGMA analysis was carried out on each gene region of dengue virus and demonstrated that outcome from most of the gene regions showed similar results except those from NS4B and YUTR with very short nucleotide length. Among ten regions examined, the results from E gene documented the geographical differences of the virus strains most clearly and all the American strains (Mara 4, IQT1797 and S1) were distantly related to the Asian isolates. As for the 16 Thai strains isolated in 1993, they were clustered into three groups and a strain from a DSS patient formed a distinct branch compared to the other two groups. This finding from phylogenetic analysis is consistent with earlier conclusion and support the severity related subtyping of dengue 2 virus based on amino acid changes.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Filogenia
/
Tailândia
/
Humanos
/
Proteínas Estruturais Virais
/
China
/
Proteínas não Estruturais Virais
/
Evolução Molecular
/
Regiões 3' não Traduzidas
/
Regiões 5' não Traduzidas
/
Vírus da Dengue
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
2000
Tipo de documento:
Artigo
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