Correlations in survivin expression with the expression of p53 and bcl-2 in invasive ductal carcinoma of the breast.
Southeast Asian J Trop Med Public Health
;
2007 Sep; 38(5): 904-10
Artigo
em Inglês
| IMSEAR
| ID: sea-31167
ABSTRACT
This work studied the correlations between survivin, bcl-2 and p53 in infiltrating ductal carcinoma of the breast. A total number of 382 cases were collected from 3 hospitals in northeastern Malaysia. Survivin, bcl-2 and p53 were detected by immunohistochemistry on samples prepared from tissue blocks. Significant correlations were found between tumor histological grades and tumor size and lymph node involvement. Highly significant statistical correlations (p<0.001) were found in expression of the markers under study. It is concluded that such significant correlations may imply that the alterations in the expression take place in a concerted fashion, implying that many of these cases may share common abnormalities.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Neoplasias da Mama
/
Feminino
/
Humanos
/
Imuno-Histoquímica
/
Proteína Supressora de Tumor p53
/
Apoptose
/
Carcinoma Ductal de Mama
/
Adulto
/
Proteínas Associadas aos Microtúbulos
/
Pessoa de Meia-Idade
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
2007
Tipo de documento:
Artigo
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