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Abnormalities in lung function among multiply-transfused thalassemia patients: results from a thalassemia center in Malaysia.
Southeast Asian J Trop Med Public Health ; 2005 Jan; 36(1): 265-9
Artigo em Inglês | IMSEAR | ID: sea-31372
ABSTRACT
The aim of this study was to (1) determine the prevalence and patterns of lung dysfunction among transfusion dependent thalassemics; (2) determine the associated factors that might contribute to this problem. This was a cross-sectional study involving 66 patients with transfusion dependent thalassemia aged 10 years and above. All patients underwent physical examination, standardized pulmonary function tests including spirometry, lung volume, and the carbon monoxide diffusion capacity. A restrictive pattern of lung dysfunction was observed in 22 patients (33.3%) and none showed the presence of obstructive ventilatory impairment. A reduction in the carbon monoxide diffusion capacity (DLCO) was seen 87.9% of the patients, including 7.6% who had evidence of hypoxemia. Ten patients showed a reduction in the FEF25-75% although they did not fulfil the criteria for small airway disease. No correlation was found between lung dysfunction and serum ferritin levels in the patients. Restrictive lung dysfunction and diffusion impairment were the predominant abnormalities found in our cohort of patients.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Talassemia / Transfusão de Sangue / Feminino / Humanos / Masculino / Oximetria / Criança / Capacidade de Difusão Pulmonar / Prevalência / Estudos Transversais Tipo de estudo: Estudo observacional / Estudo de prevalência / Fatores de risco País/Região como assunto: Ásia Idioma: Inglês Revista: Southeast Asian J Trop Med Public Health Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Talassemia / Transfusão de Sangue / Feminino / Humanos / Masculino / Oximetria / Criança / Capacidade de Difusão Pulmonar / Prevalência / Estudos Transversais Tipo de estudo: Estudo observacional / Estudo de prevalência / Fatores de risco País/Região como assunto: Ásia Idioma: Inglês Revista: Southeast Asian J Trop Med Public Health Ano de publicação: 2005 Tipo de documento: Artigo