Quinine toxicity when given with doxycycline and mefloquine.
Southeast Asian J Trop Med Public Health
;
1994 Jun; 25(2): 397-400
Artigo
em Inglês
| IMSEAR
| ID: sea-31622
ABSTRACT
The pharmacokinetic and dynamic interactions among 3 antimalarials, ie quinine, doxycycline and mefloquine was observed in a 26-year-old Thai male patient with falciparum malaria. During the acute episode of the infection, the patient was treated with an intravenous dose of quinine hydrochloride at 600 mg qid, together with an oral dose of doxycycline 100 mg bid. Due to nausea, tinnitus and the persistence of parasitemia in peripheral blood smears, the dose of quinine was reduced 2 days after the first treatment to 300 mg; concurrently oral mefloquine 750 mg was given as 2 divided doses at 24 hours apart. During the course of treatment, the patient developed hearing loss; deafness of the right ear lasted for one week after stopping quinine administration. Higher plasma quinine and lower whole blood mefloquine concentrations than would be expected from the simulation profiles were detected 4 days after the first treatment. However, the concentration of mefloquine was increased upon the cessation of quinine treatment.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Quinina
/
Humanos
/
Masculino
/
Mefloquina
/
Malária Falciparum
/
Doxiciclina
/
Adulto
/
Quimioterapia Combinada
/
Transtornos da Audição
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1994
Tipo de documento:
Artigo
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