Acute hemodynamic effects of sildenafil in patients with idiopathic dilated cardiomyopathy.
Indian Heart J
;
2008 Nov-Dec; 60(6): 599-601
Artigo
em Inglês
| IMSEAR
| ID: sea-3186
ABSTRACT
Sildenafil, a phosphodiestrase-5 inhibitor, decreases pulmonary artery pressures (PAP) in patients with idiopathic pulmonary hypertension. There is little data pertaining to its use in unselected patients with idiopathic dilated cardiomyopathy (IDCM). A single oral dose of sildenafil (50 mg) was administered to 11 patients (mean age 44.9 +/- 7 years, 7 males) with IDCM with left ventricular ejection fraction < or = 40% in New York Heart Association class II/III at the time of right heart catheterization. There was a significant decrease in pulmonary artery systolic pressure (from 31.5 +/- 9.7 to 19.0 +/- 5.2 mmHg, p < 0.001) and pulmonary vascular resistance (PVR) (from 3.0 +/- 2.1 to 1.6 +/- 0.8 dyne/s/m(2)/cm(5), p = 0.01) following sildenafil administration. The systemic vascular resistance (SVR) and pulmonary wedge capillary pressure also significantly decreased. No significant differences in heart rate, cardiac index and PVR/SVR ratio were observed. There were no side effects documented. Sildenafil produces favorable vasodilation in both pulmonary and systemic vascular beds with decrease in left ventricular filling pressures, in stable patients with IDCM.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Piperazinas
/
Artéria Pulmonar
/
Purinas
/
Sulfonas
/
Vasodilatadores
/
Pressão Sanguínea
/
Feminino
/
Humanos
/
Masculino
/
Débito Cardíaco
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
Indian heart j
Ano de publicação:
2008
Tipo de documento:
Artigo
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