Laboratory assessment of thrombolytic therapy in acute myocardial infarction.
Southeast Asian J Trop Med Public Health
;
1993 ; 24 Suppl 1(): 144-8
Artigo
em Inglês
| IMSEAR
| ID: sea-32108
ABSTRACT
Hemostatic profiles and cardiac enzymes were studied in 55 acute myocardial infarct (AMI) patients to assess SK and rt-PA therapy. Hypofibrinogenemia occurred 85% in SK group and 55% in rt-PA group with high FDP and D-Dimer, indicating systemic fibrinogenolysis and local crosslinked fibrin clot lysis. The incidence of bleeding in SK and rt-PA groups combined with anticoagulants were the same but lower in rt-PA with antiplatelet. The mean FDP was significantly higher in the bleeding group (p < 0.01). Cardiac enzymes CK, CK-MB peak values indicated reperfusion were 26.6%, 60% and 90% in conventional, SK and rt-PA therapy, respectively. Early and late occlusion did not occur either in SK or rt-PA followed by anticoagulants. Late occlusion was found in patients treated with rt-PA and antiplatelet. Mortality rate was 20% in conventional therapy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Estreptoquinase
/
Varfarina
/
Transtornos da Coagulação Sanguínea
/
Testes de Coagulação Sanguínea
/
Feminino
/
Humanos
/
Masculino
/
Heparina
/
Monitoramento de Medicamentos
/
Ativador de Plasminogênio Tecidual
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1993
Tipo de documento:
Artigo
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