Structure-activity relationships of dengue antiviral polycyclic quinones.
Southeast Asian J Trop Med Public Health
;
2005 Jul; 36(4): 901-5
Artigo
em Inglês
| IMSEAR
| ID: sea-32284
ABSTRACT
The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Hidrocarbonetos Policíclicos Aromáticos
/
Quinonas
/
Relação Estrutura-Atividade
/
Estrutura Molecular
/
Vírus da Dengue
/
Animais
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
2005
Tipo de documento:
Artigo
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