K-ras oncogene and p53 gene mutations in cholangiocarcinoma from Thai patients.
Southeast Asian J Trop Med Public Health
;
1998 Mar; 29(1): 71-5
Artigo
em Inglês
| IMSEAR
| ID: sea-32390
ABSTRACT
Paraffin embedded tissues from twenty Thai patients with intrahepatic cholangiocarcinomas were studied for K-ras gene mutations at codon 12, 13 and 61 and for p53 gene mutations in exon 5 to 8 using polymerase chain reaction and thermal cycle sequencing. Results showed that point mutations at these regions in K-ras oncogene were not present in all the samples. One case harbored a p53 gene mutation in codon 282 in exon 8, CGG (arginine) to TGG (tryptophan), but the mutation was not found in other patient's tissues with similar histological features.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tailândia
/
Neoplasias dos Ductos Biliares
/
Ductos Biliares Intra-Hepáticos
/
Feminino
/
Humanos
/
Masculino
/
Reação em Cadeia da Polimerase
/
Genes p53
/
Genes ras
/
Colangiocarcinoma
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1998
Tipo de documento:
Artigo
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