Investigation of the anti-acetylcholinesterase activities of the antimalarial agent, amodiaquine, and related compounds.
Southeast Asian J Trop Med Public Health
;
1981 Mar; 12(1): 37-41
Artigo
em Inglês
| IMSEAR
| ID: sea-32552
ABSTRACT
The antimalarial agent, amodiaquine, is a potent inhibitor of AChE (Ki = 1.50 x 10(-9) M, pH 7.4, 25 degrees C). Both the protonated diethylamino and phenolic hydroxyl functions of amodiaquine are necessary for interaction with AChE. This suggests that the inhibition of AChE by amodiaquine may involve binding of the protonated diethylamino and phenolic hydroxyl functions to the anionic and esteric sites of the enzyme respectively. The anti-AChE property of amodiaquine may be related in some way to the gastrointestinal and central nervous system disturbances frequently encountered when large doses of amodiaquine are used for the treatment of malaria.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Relação Estrutura-Atividade
/
Química
/
Inibidores da Colinesterase
/
Fenômenos Químicos
/
Amodiaquina
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1981
Tipo de documento:
Artigo
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