Biochemical aspects of drug action and resistance in malaria parasites.
Southeast Asian J Trop Med Public Health
;
1985 Sep; 16(3): 459-72
Artigo
em Inglês
| IMSEAR
| ID: sea-32595
ABSTRACT
Biochemical aspects of action of antifolates and 4-aminoquinolines and their resistance in the malaria parasites are reviewed, with emphasis on pyrimethamine and chloroquine respectively. Resistance to pyrimethamine has been shown to be associated with either an increase in the amount of parasite dihydrofolate reductase or a reduced affinity of the enzyme for drug binding, in line with the presence of a distinctive pathway for folate metabolism. The theories for drug synergism in the folate pathway are discussed with respect to resistance to pyrimethamine and its combination with sulpha drugs. The biochemical basis for chloroquine resistance is still unclear, reflecting incomplete understanding of its mechanism of action. Data implicating the role of haemozoin and other components as a putative chloroquine receptor of the parasites are reviewed, and possible explanations for resistance are discussed.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Plasmodium
/
Pirimetamina
/
Sulfanilamidas
/
Resistência Microbiana a Medicamentos
/
Cloroquina
/
Sinergismo Farmacológico
/
Ácido Fólico
/
Antagonistas do Ácido Fólico
/
Aminoquinolinas
/
Hemina
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1985
Tipo de documento:
Artigo
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