Treatment of Opisthorchiasis viverrini in hamsters with albendazole.

ABSTRACT

Efficacy of many drugs against Opisthorchis viverrini in man were shown by the percentages of egg reduction and the absence of egg in faeces. In some cases, however, the eggs reappeared after a period of time. The pathological changes of the bile duct could cause partial or even complete obstruction of the bile passages, thus resulting in the occurrence of natural egg reduction. Albendazole, a broad spectrum anthelmintic was used to treat opisthorchiasis viverrini in hamsters. At dosage of 100 mg per kg body weight twice daily for three consecutive days, the drug yielded an average of 81.5% of worm reduction at four months after medication. In this study complete cure was not obtained.