HTLV-I antibody study in normal individuals and unselected hospital patients in Malaysia.
Southeast Asian J Trop Med Public Health
;
1992 Mar; 23(1): 26-9
Artigo
em Inglês
| IMSEAR
| ID: sea-32881
ABSTRACT
A serological investigation for human T cell leukemia virus I (HTLV-I) infection was carried out at the University Hospital, Kuala Lumpur. A total of 626 sera from a non-patient population and 1,038 sera from unselected in-patients were screened for HTLV-I antibodies using an enzyme-linked immunosorbent assay (ELISA). 27/1664 (1.6%) were found to be reactive. However, on Western blotting, only 2 sera were confirmed positive, both showing reactions for the major core (p19 and p24) and the envelope (gp46) proteins. Both of the serum samples were from unselected hospital patients. Most of the remaining sera which were reactive on screening showed indeterminate results on Western blotting. These were further tested by radioimmunoprecipitation assay (RIPA) and none of these sera gave a positive reaction. Therefore, only 2/1038 (0.19%) unselected patients could be confirmed to have antibodies to HTLV-I. None of the normal individuals screened showed a positive Western blot result. Our data indicate that HTLV-I infection is present in our population, but at a low prevalence rate.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Masculino
/
Ensaio de Imunoadsorção Enzimática
/
Antígenos de Deltaretrovirus
/
Anticorpos Anti-HTLV-I
/
Infecções por HTLV-I
/
Etnicidade
/
Ensaio de Radioimunoprecipitação
/
Estudos Soroepidemiológicos
/
Programas de Rastreamento
Tipo de estudo:
Estudo diagnóstico
/
Estudo de prevalência
/
Estudo prognóstico
/
Estudo de rastreamento
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1992
Tipo de documento:
Artigo
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