A sensitive assay for anti-HIV-1 drug discovery in a biological safety level-2 laboratory.
Southeast Asian J Trop Med Public Health
;
1998 Dec; 29(4): 758-62
Artigo
em Inglês
| IMSEAR
| ID: sea-33137
ABSTRACT
Studies involving infectious, wild type HIV-1 must be performed under strict BSL-3 practice. We have employed a defective (deltaTat/Rev)MC99 and cloned 1A2 line, ie, mutated HIV-1 and Tat/Rev transfected cells to verify anti-HIV-1 activity in a BSL-2 laboratory. A number of extracts from various parts of 11 species of plants were studied. Results were correlated with those of an anti-HIV-1 reverse transcriptase (RT) assay.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Bioensaio
/
Humanos
/
Extratos Vegetais
/
Desenho de Fármacos
/
Células Gigantes
/
Inibidores da Transcriptase Reversa
/
Fármacos Anti-HIV
/
Citoproteção
/
Transcriptase Reversa do HIV
/
Infecção Laboratorial
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1998
Tipo de documento:
Artigo
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