Efficacy of single-dose mebendazole, polymorphic forms A and C, in the treatment of hookworm and Trichuris infections.
Southeast Asian J Trop Med Public Health
;
1993 Dec; 24(4): 712-6
Artigo
em Inglês
| IMSEAR
| ID: sea-33373
ABSTRACT
A therapeutic trial of single mebendazole, 300 mg polymorph A, 300 mg polymorph C and 500 mg polymorph C, in the treatment of hookworm and Trichuris infections was carried out at primary schools in Southern Thailand. The total of 958 children were randomly allocated in seven treatment groups including the placebo control and the standard dose control (100 mg polymorph C bid for 3 days). The egg reduction rates and the cure rates of 300 mg and 500 mg polymorph C were similar, but inferior to those of the standard dose in both hookworm and Trichuris infections. The efficacy of single dose 300 mg polymorph A was not different from that of the placebo control (alpha = 0.05) in both infections.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Contagem de Ovos de Parasitas
/
Tricuríase
/
Feminino
/
Humanos
/
Masculino
/
Criança
/
Relação Dose-Resposta a Droga
/
Fezes
/
Infecções por Uncinaria
/
Mebendazol
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1993
Tipo de documento:
Artigo
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