Immunization of laboratory animals with ultraviolet-attenuated larvae against homologous challenge infection with Trichinella britovi.
Southeast Asian J Trop Med Public Health
;
1998 Sep; 29(3): 563-6
Artigo
em Inglês
| IMSEAR
| ID: sea-33562
ABSTRACT
Immunogenicity of Trichinella britovi (Japanese isolate, cord ISS 408) muscle larvae irradiated with 5 mJ/cm2 of short wavelength ultraviolet (UV) was studied using homologous challenge infections. SCID mice vaccinated with UV-attenuated larvae showed no resistance, although its congenic CB-17 mice exhibited remarkable immunity. Following challenge vaccinated Mongolian gerbils, Meriones unguiculatus, did not show significant immunity. Use of these animal models vaccinated with UV-attenuated larvae will contribute to the investigation of immune mechanisms against Trichinella infection and also to the development of a vaccine of trichinellosis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Especificidade da Espécie
/
Trichinella
/
Triquinelose
/
Masculino
/
Gerbillinae
/
Vacinação
/
Camundongos SCID
/
Camundongos Congênicos
/
Larva
/
Animais
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1998
Tipo de documento:
Artigo
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